Abstract: Posterior vitreous detachment (PVD) in diabetic retinopathy (DR) has played an important role in the development process, and outcome of surgical treatment. Partial PVD can contribute to the worsening of DR. Neovascularization on the retinal surface cannot occur without an appropriate scaffold of collagenous material, complete PVD can eliminate the scaffold, reduce vitreous hemorrhage, increase vitreal oxygen levels, make surgery easier and safer.Intravitreal injection of plasmin and other drugs with little side effects can induce PVD, improve the surgical outcome of DR and reduce surgical complications.  (Int Rev Ophthalmol, 2015, 39： 116-120)